Reproduction Abstracts

Introduction: Genome-wide analysis of DNA methylation in mammalian preimplantation embryos, particularly at the single embryo level, will be of particular use for assessing the epigenetic status and health of in vitro-derived embryos, including humans. To date, single embryo DNA methylation analysis has been limited to a small number of genes (<5). In this study we used an adaptation of reduced representation bisulfite sequencing (RRBS) to i) perform genome-wide a...